WNT/β-catenin pathway -> disregulation in melanoma
G007LK -> decreases WNT/β-catenin signaling
Two data sets and two metadata sets (mouse and human)
Goal was to identify up and down regulated genes after G007LK treatment
Many zero expressions through cell lines in each of treatment
Approximately equal amounts of significantly regulated genes in each treatment
However, the overlap is very small
PCA analysis across 18 human cell lines
In our mouse model, the BVES gene appears to be the most significantly impacted.This gene contributes to regeneration processes
Our holistic investigation across mouse and human melanoma cell lines provided valuable insights into the influences of the studied compounds and G007.LK effects on their gene expression patterns
More extensive work is needed to fully understand the impact of the G007.LK in gene expression and cellular pathway across different melanoma cells
R for Bio Data Science